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Navigating Elizabeth's Velvet Room quests in Persona 3 Reload often requires players to hunt down specific items across Tatsumi Port Island. One prompt that frequently leaves players searching is Request 20, which asks you to bring her a dose of potent medicine. Finding this item is simple once you know which staff member at Gekkoukan High School to consult.
Understanding Elizabeth Request 20
Elizabeth unlocks Request 20 during the middle of June as you progress further through Tartarus. Unlike standard combat challenges, this task focuses entirely on exploring your daily high school environment. Accepting the request activates the flag necessary to claim the quest item from campus.
Completing this errand yields valuable rewards that aid your ongoing Persona fusions and dungeon exploration. Because there is no strict calendar deadline, you can complete it at your own pace during school days. However, acquiring it early helps clear room for subsequent Velvet Room requests.
Where to Find the Potent Medicine Location
The Potent Medicine is located directly inside Gekkoukan High School on the first floor. You must head toward the hallway housing the faculty rooms and enter the Nurse's Office. Inside, you will interact with the eccentric school nurse and teacher, Mr. Edogawa.
Visiting the Nurse's Office on any standard school day after accepting the quest triggers a special interaction. Mr. Edogawa will hand over the medicine during your conversation without consuming any time. You do not need to be feeling sick or tired to retrieve this specific key item.
How to Complete the Request and Hand Over the Item
Once the Potent Medicine is added to your inventory, exit the school grounds and travel to Paulownia Mall or the Tartarus entrance. Enter the Velvet Room to speak with Elizabeth and turn in Request 20. She will accept the medicine and grant your reward immediately.
Delivering the medicine frees up your active request slots so you can accept higher-level tasks. Tracking down school-based items remains one of the most reliable ways to maintain steady progress with Elizabeth's rewards. Paying attention to campus NPCs ensures you never miss crucial quest triggers.